Marie Therese Coin-Coin, an enslaved woman, and Claude Thomas Pierre Metoyer, her French owner had many children together after Coin-Coin was freed. On land acquired by land grants, the Yucca House and the African House was built. The Yucca House remained the large structure on the plantation until 1833 when the main house, known as Melrose, was built.
After 1884, Melrose Plantation became a hub of art and education under the ownership of John Hampton Henry and Miss Cammie Garrett Henry. Miss Cammie, as she became known, made Melrose a haven for artists and writers.